Nagaraju, Anugula ; Janaki Ramulu, B. ; Shukla, Gaurav ; Srivastava, Abhijeet ; Verma, Girijesh Kumar ; Raghuvanshi, Keshav ; Singh, Maya Shankar (2015) A facile and highly convergent approach to thiazolo[3,2-a]pyridines via one-pot multicomponent domino reaction under metal-free and solvent-free conditions Tetrahedron, 71 (21). pp. 3422-3427. ISSN 0040-4020
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Official URL: http://doi.org/10.1016/j.tet.2015.03.087
Related URL: http://dx.doi.org/10.1016/j.tet.2015.03.087
Abstract
Operationally and user-simple a highly efficient one-pot three-component (5 molecules) coupling of α-enolic dithioesters, cysteamine hydrochloride and aldehydes afforded a range of thiazolopyridines in high yields under metal-free and solvent-free conditions. The new domino protocol generated two rings by the concomitant formation of seven multiple bonds (two C–C, three C–N and two C–S) involving a sequence of N,S-acetal formation/double Michael addition/N-cyclization as key steps in a single operation.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 119616 |
| Deposited On: | 15 Jun 2021 06:39 |
| Last Modified: | 15 Jun 2021 06:39 |
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