Metal-free aerobic one-pot synthesis of substituted/annulated quinolines from alcohols via indirect Friedländer annulation

Anand, Namrata ; Koley, Suvajit ; Ramulu, B. Janaki ; Singh, Maya Shankar (2015) Metal-free aerobic one-pot synthesis of substituted/annulated quinolines from alcohols via indirect Friedländer annulation Organic and Biomolecular Chemistry, 13 (37). pp. 9570-9574. ISSN 1477-0520

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Official URL: http://doi.org/10.1039/C5OB01422K

Related URL: http://dx.doi.org/10.1039/C5OB01422K

Abstract

Metal-free, operationally simple, and highly efficient one-pot aerobic process for the synthesis of functionalized/annulated quinolines is devised from easily available 2-aminobenzyl alcohol/2-aminobenzophenones and alkyl/aryl alcohols for the first time. The process involves two sequential reactions, namely in situ aerial oxidation of alcohols to the corresponding aldehydes/ketones followed by Friedländer annulation.

Item Type:Article
Source:Copyright of this article belongs to The Royal Society of Chemistry.
ID Code:119613
Deposited On:15 Jun 2021 06:27
Last Modified:15 Jun 2021 06:27

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