Shinde, U. P. ; Guru Row, T. N. ; Mawal, Y. R. (1989) Export of proteins across membranes: the helix reversion hypothesis Bioscience Reports, 9 (6). pp. 737-745. ISSN 0144-8463
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Official URL: http://www.springerlink.com/index/U139R31252586421...
Related URL: http://dx.doi.org/10.1007/BF01114812
Abstract
A model is presented which explains the biological role of the leader peptide in protein export. Along the lines of this model, the conformational changes of a protein with environment serves as a general mechanism for translocation. The leader peptide in the cytoplasm takes a hairpin like conformation which reverts to an extended helix upon integration into the membrane. The essential features of this model are in accord with recent results of protein export.
Item Type: | Article |
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Source: | Copyright of this article belongs to Portland Press Limited. |
Keywords: | Protein Export; Conformational Changes; Leader Peptides; Hairpin Helix |
ID Code: | 11946 |
Deposited On: | 13 Nov 2010 13:31 |
Last Modified: | 16 May 2016 21:21 |
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