Total Synthesis and Biological Activity of 13,14-Dehydro-12-Oxo-Phytodienoic Acids (Deoxy-J1-Phytoprostanes)

Iqbal, Mazhar ; Evans, Paul ; Lledó, Agustí ; Verdaguer, Xavier ; Pericàs, Miquel A. ; Riera, Antoni ; Loeffler, Christiane ; Sinha, Alok K. ; Mueller, Martin J. (2004) Total Synthesis and Biological Activity of 13,14-Dehydro-12-Oxo-Phytodienoic Acids (Deoxy-J1-Phytoprostanes) ChemBioChem, 6 (2). pp. 276-280. ISSN 1439-4227

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Official URL: http://doi.org/10.1002/cbic.200400259

Related URL: http://dx.doi.org/10.1002/cbic.200400259

Abstract

Non-enzymatic oxidation of linolenate yields a series of prostaglandin-like stress metabolites including racemic deoxy-J1-phytoprostanes (1) that are structurally related to 12-oxo-phytodienoic acid (2). Naturally occurring isomers of 1 were prepared by total synthesis and tested in three bioassay systems to reveal potent jasmonate-like activities.

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Deposited On:10 Jun 2021 06:53
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