Gangadhar, B.N. ; Jayakumar, P.N. ; Subbakrishna, D.K. ; Janakiramaiah, N. ; Keshavan, M.S. (2004) Basal Ganglia High-Energy Phosphate Metabolism in Neuroleptic-Naive Patients With Schizophrenia: A 31-Phosphorus Magnetic Resonance Spectroscopic Study American Journal of Psychiatry, 161 (7). pp. 1304-1306. ISSN 0002-953X
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Official URL: http://doi.org/10.1176/appi.ajp.161.7.1304
Related URL: http://dx.doi.org/10.1176/appi.ajp.161.7.1304
Abstract
OBJECTIVE: This study used 31-phosphorus magnetic resonance spectroscopy (31P MRS) to investigate basal ganglia abnormalities in neuroleptic-naive patients with schizophrenia. METHOD: Nineteen schizophrenia patients and 31 age- and sex-matched healthy comparison subjects underwent 31P MRS. RESULTS: The phosphocreatine/total phosphorus and phosphocreatine/total ATP ratios in both basal ganglia were significantly lower in patients. CONCLUSIONS: Schizophrenia patients showed features of increased metabolism in the basal ganglia consistent with impaired activity of the frontostriatal pathways.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Cambridge University Press. Copyright of this article belongs to American Psychiatric Publishing Inc. |
| ID Code: | 119169 |
| Deposited On: | 08 Jun 2021 11:48 |
| Last Modified: | 08 Jun 2021 11:48 |
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