β2-Microglobulin abnormalities in antipsychotic-naïve schizophrenia: Evidence for immune pathogenesis

Chittiprol, Seetharamaiah ; Venkatasubramanian, Ganesan ; Neelakantachar, Narendran ; Allha, Naveen ; Shetty, Kurudunje Taranath ; Gangadhar, Bangalore N. (2009) β2-Microglobulin abnormalities in antipsychotic-naïve schizophrenia: Evidence for immune pathogenesis Brain, Behavior, and Immunity, 23 (2). pp. 189-192. ISSN 0889-1591

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Official URL: http://doi.org/10.1016/j.bbi.2008.08.007

Related URL: http://dx.doi.org/10.1016/j.bbi.2008.08.007

Abstract

Studies examining immune dysfunction in schizophrenia have reported decreased type-1 T-helper cell specific immunity (Th1) and increased type-2 T-helper cell specific immunity (Th2) and related abnormalities in inflammatory system. β2-Microglobulin (β2M) influences the development of dendritic cells, which play a significant role in regulating the differentiation of naive CD4+ T cells into Th1 or Th2 lineages. The present study examined serum β2M in antipsychotic-naïve schizophrenia patients (n = 43) in comparison with age, sex, handedness and socioeconomic status matched healthy controls (n = 43). Serum β2M was significantly higher in schizophrenia patients (1692.6 ± 354.4 ng/mL) than healthy controls (1409.6 ± 246.9 ng/mL) (t = 4.3; p < 0.0001). There was a significant positive correlation between β2M level and total psychopathology score (r = 0.32; p = 0.035). These novel observations suggest that β2M abnormalities might have a potential association with the pathogenesis of schizophrenia.

Item Type:Article
Source:Copyright of this article belongs to Elsevier B.V..
Keywords:Schizophrenia; Β2-Microglobulin; MHC; Th1–th2 Imbalance Hypothesis.
ID Code:119100
Deposited On:08 Jun 2021 05:35
Last Modified:08 Jun 2021 05:35

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