Thirthalli, J. ; Venkatesh, B. K. ; Kishorekumar, K. V. ; Arunachala, U. ; Venkatasubramanian, G. ; Subbakrishna, D. K. ; Gangadhar, B. N. (2009) Prospective comparison of course of disability in antipsychotic-treated and untreated schizophrenia patients Acta Psychiatrica Scandinavica, 119 (3). pp. 209-217. ISSN 0001-690X
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Official URL: http://doi.org/10.1111/j.1600-0447.2008.01299.x
Related URL: http://dx.doi.org/10.1111/j.1600-0447.2008.01299.x
Abstract
Objective: To compare the course of disability in schizophrenia patients receiving antipsychotics and those remaining untreated in a rural community. Method: Of 215 schizophrenia patients identified in a rural south Indian community, 58% were not receiving antipsychotics. Trained raters assessed the disability in 190 of these at baseline and after 1 year. The course of disability in those who remained untreated was compared with that in those who received antipsychotics. Results: Mean disability scores remained virtually unchanged in those who remained untreated, but showed a significant decline (indicating decrement in disability) in those who continued to receive antipsychotics and in those in whom antipsychotic treatment was initiated (P < 0.001; group × occasion effect). The proportion of patients classified as ‘disabled’ declined significantly in the treated group (P < 0.01), but remained the same in the untreated group. Conclusion: Disability in untreated schizophrenia patients remains unchanged over time. Treatment with antipsychotics in the community results in a considerable reduction in disability.
Item Type: | Article |
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Source: | Copyright of this article belongs to John Wiley & Sons, Inc. |
Keywords: | Disability; Antipsychotics; Schizophrenia. |
ID Code: | 119098 |
Deposited On: | 08 Jun 2021 05:31 |
Last Modified: | 08 Jun 2021 05:31 |
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