Venkatasubramanian, Ganesan ; Arasappa, Rashmi ; Rao, Naren P. ; Behere, Rishikesh V. ; Kalmady, Sunil ; Gangadhar, Bangalore N. (2010) Inverse relationship between serum high density lipoprotein and negative syndrome in antipsychotic-naive schizophrenia Clinical Chemistry and Laboratory Medicine, 48 (1). ISSN 1434-6621
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Official URL: http://doi.org/10.1515/CCLM.2010.004
Related URL: http://dx.doi.org/10.1515/CCLM.2010.004
Abstract
Background: Recent literature suggests a role for apolipoprotein L (apoL) aberrations in the pathogenesis of schizophrenia. ApoL is almost exclusively associated with apolipoprotein A-I in high-density lipoproteins (HDLs). The objective of this study was to examine the correlation between symptom scores and serum HDL in antipsychotic-naive schizophrenia patients. Methods: In this cross-sectional study, 60 antipsychotic-naive schizophrenia patients were systematically examined for their symptom scores, with good inter-rater reliability. Concurrently, an overnight fasting serum lipid profile from these patients was assessed. Results: Serum HDL had a significant inverse correlation with a total negative syndrome score (rho=-0.43; p=0.001). Conclusions: The study observation supports the potential role for HDL abnormalities in the genesis of negative symptoms in schizophrenia.
Item Type: | Article |
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Source: | Copyright of this article belongs to Walter de Gruyter GmbH & Co. KG. |
ID Code: | 119085 |
Deposited On: | 08 Jun 2021 04:59 |
Last Modified: | 08 Jun 2021 04:59 |
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