Benekareddy, Madhurima ; Vadodaria, Krishna C. ; Nair, Amrita R. ; Vaidya, Vidita A. (2011) Postnatal Serotonin Type 2 Receptor Blockade Prevents the Emergence of Anxiety Behavior, Dysregulated Stress-Induced Immediate Early Gene Responses, and Specific Transcriptional Changes that Arise Following Early Life Stress Biological Psychiatry, 70 (11). pp. 1024-1032. ISSN 0006-3223
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Official URL: http://doi.org/10.1016/j.biopsych.2011.08.005
Related URL: http://dx.doi.org/10.1016/j.biopsych.2011.08.005
Abstract
Early life adverse experience contributes to an enhanced vulnerability for adult psychopathology. Recent evidence indicates that serotonin type 2 (5-HT(2)) receptor function, implicated in the pathophysiology of mood and anxiety disorders, is significantly enhanced in the maternal separation model of early life stress. We examined whether postnatal 5-HT(2) receptor blockade would prevent the consequences of maternal separation on anxiety behavior and dysregulated gene expression
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Society of Biological Psychiatry. |
| ID Code: | 119043 |
| Deposited On: | 07 Jun 2021 08:00 |
| Last Modified: | 07 Jun 2021 08:00 |
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