Rao, Rammohan V. ; Gnanamuthu, Chandran ; Balasubramanian, Aiylam S. (1989) Human cerebrospinal fluid acetylcholinesterase and butyrylcholinesterase. Evidence for identity between the serum and cerebrospinal fluid butyrylcholinesterase Clinica Chimica Acta, 183 (2). pp. 135-145. ISSN 0009-8981
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000989...
Related URL: http://dx.doi.org/10.1016/0009-8981(89)90329-X
Abstract
Human cerebrospinal fluid contained both acetylcholinesterase (EC 3.1.1.7) and butyrylcholinesterase (EC 3.1.1.8) and they were estimated in the presence of selective inhibitors. Butyrylcholinesterase of human cerebrospinal fluid was similar to human serum butyrylcholinesterase in its electrophoretic mobility, glycoprotein nature and tyramine activation of the aryl acylamidase (EC 3.5.1.13) activity exhibited by butyrylcholinesterase. Moreover antibody raised against human serum purified butyrylcholinesterase could completely immunoprecipitate butyrylcholinesterase from human cerebrospinal fluid without affecting acetylcholinesterase. It is suggested that a useful method for the precise determination of acetylcholinesterase in human cerebrospinal fluid would be removal of butyrylcholinesterase by immunoprecipitation using antibody raised against human serum butyrylcholinesterase.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Acetylcholinesterase; Butyrylcholinesterase; Aryl Acylamidase; Human Cerebrospinal Fluid; Human Serum |
| ID Code: | 1189 |
| Deposited On: | 05 Oct 2010 12:47 |
| Last Modified: | 13 May 2011 05:32 |
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