Relationship Between Corpus Callosum Abnormalities and Schneiderian First-Rank Symptoms in Antipsychotic-Naïve Schizophrenia Patients

Rao, Naren P. ; Venkatasubramanian, Ganesan ; Arasappa, Rashmi ; Gangadhar, Bangalore N. (2011) Relationship Between Corpus Callosum Abnormalities and Schneiderian First-Rank Symptoms in Antipsychotic-Naïve Schizophrenia Patients The Journal of Neuropsychiatry and Clinical Neurosciences, 23 (2). pp. 155-162. ISSN 0895-0172

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Official URL: http://doi.org/10.1176/jnp.23.2.jnp155

Related URL: http://dx.doi.org/10.1176/jnp.23.2.jnp155

Abstract

The corpus callosum (CC), has been hypothesized to be implicated in the pathogenesis of schizophrenia; however, the findings from magnetic resonance imaging studies are conflicting. Moreover, the relationship between first-rank-symptoms (FRS) and CC abnormalities in schizophrenia is yet to be examined. The authors examined CC morphometry, based on Witelson's method, in antipsychotic-naïve-schizophrenia patients in comparison with matched healthy-control subjects. Patients had significantly smaller CC, splenium, and isthmus areas than control subjects. A novel finding of the study is that only those without FRS differed from control subjects, but not those with FRS. Study findings support a neuro-developmental hypothesis and possible connectivity abnormalities in symptom-genesis.

Item Type:Article
Source:Copyright of this article belongs to American Psychiatric Association.
ID Code:118829
Deposited On:30 May 2021 06:11
Last Modified:30 May 2021 06:11

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