Raveendranathan, Dhanya ; Sharma, Eesha ; Venkatasubramanian, Ganesan ; Rao, Mukund G. ; Varambally, Shivarama ; Gangadhar, Bangalore N. (2013) Late-onset clozapine-induced agranulocytosis in a patient with comorbid multiple sclerosis General Hospital Psychiatry, 35 (5). 574.e5-574.e6. ISSN 0163-8343
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Official URL: http://doi.org/10.1016/j.genhosppsych.2012.07.001
Related URL: http://dx.doi.org/10.1016/j.genhosppsych.2012.07.001
Abstract
The risk of clozapine-induced agranulocytosis is highest in the initial 6 months after onset of treatment. There have been very few reports of neutropenia and agranulocytosis after this period. We report a unique case of delayed clozapine-induced agranulocytosis in a patient with preexisting multiple sclerosis (MS) which was treated with granulocyte colony-stimulating factor. Both MS and clozapine-induced agranulocytosis have an underlying autoimmune immune mechanism. This case highlights the need for frequent blood count monitoring on clozapine even after the initial 6 months of starting treatment especially in patients with a past history of drop in white blood cell counts as well as with a comorbid autoimmune disorder.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Inc. |
| Keywords: | Clozapine; Agranulocytosis; Multiple Sclerosis. |
| ID Code: | 118750 |
| Deposited On: | 28 May 2021 10:36 |
| Last Modified: | 28 May 2021 10:36 |
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