Mehta, Urvakhsh Meherwan ; Thirthalli, Jagadisha ; Basavaraju, Rakshathi ; Gangadhar, Bangalore N. (2014) Association of intracortical inhibition with social cognition deficits in schizophrenia: Findings from a transcranial magnetic stimulation study Schizophrenia Research, 158 (1-3). pp. 146-150. ISSN 0920-9964
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Official URL: http://doi.org/10.1016/j.schres.2014.06.043
Related URL: http://dx.doi.org/10.1016/j.schres.2014.06.043
Abstract
Abnormal cortical-inhibition has been hypothesized to underlie social-cognition deficits in schizophrenia. Studies using transcranial magnetic stimulation (TMS) as a neurophysiological probe have demonstrated cortical-inhibition deficits in this group. We compared TMS-measured short- and long-interval intracortical-inhibition (SICI & LICI) in antipsychotic-naïve (n = 33) and medicated (n = 21) schizophrenia patients and in healthy comparison subjects (n = 45). We also studied the association between cortical-inhibition and social-cognition deficits in the patients. Antipsychotic-naïve patients had significant deficits in SICI (i.e., less inhibitory response). In this group, SICI had significant inverse correlations with emotion processing and a global social-cognition score. Impaired intracortical-inhibition may thus contribute to social-cognition deficits in schizophrenia.
Item Type: | Article |
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Source: | Copyright of this article belongs to Elsevier Science. |
Keywords: | Cortical Inhibition; Social Cognition; Psychosis; GABA; Antipsychotics; Neurobiology. |
ID Code: | 118638 |
Deposited On: | 26 May 2021 11:16 |
Last Modified: | 26 May 2021 11:17 |
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