Suneetha, Lavanya M. ; Satish, Posettihalli R. ; Korula, Ravi J. ; Suneetha, Sujai K. ; Job, Charles K. ; Balasubramanian, Aiylam S. (1998) Mycobacterium leprae binds to a 25-KDa phosphorylated glycoprotein of human peripheral nerve Neurochemical Research, 23 (6). pp. 907-911. ISSN 0364-3190
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Official URL: http://www.springerlink.com/content/m7m50787361154...
Related URL: http://dx.doi.org/10.1023/A:1022471331168
Abstract
Mycobacterium leprae, the causative agent of leprosy, specifically invades and destroys the peripheral nerve, which results in the main clinical manifestation of the disease. Little is known about the bacteria-nerve protein interaction. We show in the present work that M leprae binds to a 25 kDa glycoprotein from human peripheral nerve. This protein is phosphorylatable and it binds to lectins which have alpha-mannose specificity. This M leprae-protein interaction could be of importance in the pathogenesis of leprosy.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Springer-Verlag. |
| Keywords: | Human Peripheral Nerve; Protein Phosphorylation; Mycobacterium leprae; Binding Protein |
| ID Code: | 1186 |
| Deposited On: | 05 Oct 2010 12:47 |
| Last Modified: | 13 May 2011 05:26 |
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