MADDIKA, S ; ANDE, S ; PANIGRAHI, S ; PARANJOTHY, T ; WEGLARCZYK, K ; ZUSE, A ; ESHRAGHI, M ; MANDA, K ; WIECHEC, E ; LOS, M (2007) Cell survival, cell death and cell cycle pathways are interconnected: Implications for cancer therapy Drug Resistance Updates, 10 (1-2). pp. 13-29. ISSN 1368-7646
Full text not available from this repository.
Official URL: http://doi.org/10.1016/j.drup.2007.01.003
Related URL: http://dx.doi.org/10.1016/j.drup.2007.01.003
Abstract
The partial cross-utilization of molecules and pathways involved in opposing processes like cell survival, proliferation and cell death, assures that mutations within one signaling cascade will also affect the other opposite process at least to some extent, thus contributing to homeostatic regulatory circuits. This review highlights some of the connections between opposite-acting pathways. Thus, we discuss the role of cyclins in the apoptotic process, and in the regulation of cell proliferation. CDKs and their inhibitors like the INK4-family (p16Ink4a, p15Ink4b, p18Ink4c, p19Ink4d), and the Cip1/Waf1/Kip1-2-family (p21Cip1/Waf1, p27Kip1, p57Kip2) are shown both in the context of proliferation regulators and as contributors to the apoptotic machinery. Bcl2-family members (i.e. Bcl2, Bcl-XL Mcl-1L; Bax, Bok/Mtd, Bak, and Bcl-XS; Bad, Bid, BimEL, Bmf, Mcl-1S) are highlighted both for their apoptosis-regulating capacity and also for their effect on the cell cycle progression. The PI3-K/Akt cell survival pathway is shown as regulator of cell metabolism and cell survival, but examples are also provided where aberrant activity of the pathway may contribute to the induction of apoptosis. Myc/Mad/Max proteins are shown both as a powerful S-phase driving complex and as apoptosis-sensitizers. We also discuss multifunctional proteins like p53 and Rb (RBL1/p107, RBL2/p130) both in the context of G1-S transition and as apoptotic triggers. Finally, we reflect on novel therapeutic approaches that would involve redirecting over-active survival and proliferation pathways towards induction of apoptosis in cancer cells.
Item Type: | Article |
---|---|
Source: | Copyright of this article belongs to Elsevier Science. |
Keywords: | Cell Survival; Cell Death; Cell Cycle; GADD45; PUM; NOXA; HIPK2. |
ID Code: | 118581 |
Deposited On: | 25 May 2021 13:12 |
Last Modified: | 25 May 2021 13:12 |
Repository Staff Only: item control page