Eswarappa, Sandeepa M. ; Janice, Jessin ; Balasundaram, Sudhagar V. ; Dixit, Narendra M. ; Chakravortty, Dipshikha (2009) Host-specificity of Salmonella enterica serovar Gallinarum: Insights from comparative genomics Infection, Genetics and Evolution, 9 (4). pp. 468-473. ISSN 1567-1348
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Official URL: http://doi.org/10.1016/j.meegid.2009.01.004
Related URL: http://dx.doi.org/10.1016/j.meegid.2009.01.004
Abstract
In this study, we have identified the possible genetic factors responsible for fowl-adaptation of Salmonella enterica serovar Gallinarum (S. Gallinarum). By comparing the genes related to Salmonella pathogenicity islands (SPI) of S. Gallinarum with those of Salmonella enterica serovar Enteritidis (S. Enteritidis) we have identified twenty-four positively selected genes. Our results suggest that the genes encoding the structural components of SPI-2 encoded type three secretion apparatus (TTSS) and the effector proteins that are secreted via SPI-1 encoded TTSS have evolved under positive selection pressure in these serovars. We propose that these positively selected genes play important roles in conferring different host-specificities to S. Gallinarum and S. Enteritidis.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Salmonella; Positive Selection; Host-Specificity. |
| ID Code: | 118433 |
| Deposited On: | 21 May 2021 07:02 |
| Last Modified: | 21 May 2021 07:02 |
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