Ahmed, Jasimuddin ; Sau, Samaresh Chandra ; P, Sreejyothi ; Hota, Pradip Kumar ; Vardhanapu, Pavan K. ; Vijaykumar, Gonela ; Mandal, Swadhin K. (2017) Direct C-H Arylation of Heteroarenes with Aryl Chlorides by Using an Abnormal N-Heterocyclic-Carbene-Palladium Catalyst European Journal of Organic Chemistry, 2017 (5). pp. 1004-1011. ISSN 1434-193X
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Official URL: http://doi.org/10.1002/ejoc.201601218
Related URL: http://dx.doi.org/10.1002/ejoc.201601218
Abstract
Herein, we report a versatile catalytic system for the direct C–H arylation of heteroarenes with activated aryl chloride substrates. The catalyst works successfully for a variety of heteroarenes and aryl chloride coupling partners under very low catalyst-loading conditions. We have successfully performed the direct C–H arylations of 1-methylpyrrole, 1-methylindole, furan, thiophene, furfural, and N-benzyl-1,2,3-triazole with aryl chloride partners in good yields without the use of any additives. Furthermore, we used this catalytic process to develop a one-pot synthetic protocol for the muscle relaxant dantrolene on a gram scale. Additionally, the present catalytic system can be used to perform consecutive arylations in one pot.
Item Type: | Article |
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Source: | Copyright of this article belongs to John Wiley & Sons, Inc. |
ID Code: | 118292 |
Deposited On: | 19 May 2021 19:50 |
Last Modified: | 19 May 2021 19:50 |
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