Hota, Pradip Kumar ; Sau, Samaresh Chandra ; Mandal, Swadhin K. (2018) Metal-Free Catalytic Formylation of Amides Using CO2 under Ambient Conditions ACS Catalysis, 8 (12). pp. 11999-12003. ISSN 2155-5435
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Official URL: http://doi.org/10.1021/acscatal.8b04023
Related URL: http://dx.doi.org/10.1021/acscatal.8b04023
Abstract
This study reports the metal-free formylation of amides using carbon dioxide under ambient conditions. An abnormal N-heterocyclic carbene (aNHC) acts as an efficient catalyst for the formylation of amides in the presence of hydrosilane at room temperature. This methodology enables the formation of a C–N bond and can be utilized in building up core moieties of two natural products having strong larvicidal activity such as alatamide and lansiumamide A. A preliminary mechanistic picture for this transformation has been proposed through isolation of reaction byproduct (confirmed by single crystal X-ray study) as well as by characterizing intermediates with spectroscopy.
Item Type: | Article |
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Source: | Copyright of this article belongs to American Chemical Society. |
ID Code: | 118275 |
Deposited On: | 19 May 2021 14:33 |
Last Modified: | 19 May 2021 14:33 |
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