Primary amides to amines or nitriles: a dual role by a single catalyst

Das, Hari S. ; Das, Shyamal ; Dey, Kartick ; Singh, Bhagat ; K. Haridasan, Rahul ; Das, Arpan ; Ahmed, Jasimuddin ; Mandal, Swadhin K. (2019) Primary amides to amines or nitriles: a dual role by a single catalyst Chemical Communications, 55 (79). pp. 11868-11871. ISSN 1359-7345

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Official URL: http://doi.org/10.1039/C9CC05856G

Related URL: http://dx.doi.org/10.1039/C9CC05856G

Abstract

We report a manganese-catalyzed hydrosilylative reduction of various primary amides to amines (25 examples). On simple modification of the reaction conditions such as in the presence of a catalytic amount of secondary amide, the same catalyst can transform the primary amides into intermediate nitrile compounds (16 examples) in excellent yields. This is the first example where such a controlled catalytic transformation of primary amides to amines or nitriles with a single catalyst has been demonstrated.

Item Type:Article
Source:Copyright of this article belongs to Royal Society of Chemistry.
ID Code:118252
Deposited On:19 May 2021 11:11
Last Modified:19 May 2021 11:11

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