Specialization of the general transcriptional machinery in male germ cells

Kolthur-Seetharam, Ullas ; Martianov, Igor ; Davidson, Irwin (2008) Specialization of the general transcriptional machinery in male germ cells Cell Cycle, 7 (22). pp. 3493-3498. ISSN 1538-4101

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Official URL: http://doi.org/10.4161/cc.7.22.6976

Related URL: http://dx.doi.org/10.4161/cc.7.22.6976

Abstract

In adult animals, spermatogenesis involves a continuous differentiation of the spermatogonial stem and progenitor cell population into mature sperm. A unique aspect of this developmental process is the germ cell-specific expression and function of paralogues of components of the general transcription machinery, notably subunits of TFIID. Genetic and biochemical studies show that these paralogues play critical, but mechanistically distinct roles in Drosophila and mouse spermatogenesis.

Item Type:Article
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