Candida glabrata: A Lot More Than Meets the Eye

Kumar, Kundan ; Askari, Fizza ; Sahu, Mahima ; Kaur, Rupinder (2019) Candida glabrata: A Lot More Than Meets the Eye Microorganisms, 7 (2). p. 39. ISSN 2076-2607

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Official URL: http://doi.org/10.3390/microorganisms7020039

Related URL: http://dx.doi.org/10.3390/microorganisms7020039

Abstract

Candida glabrata is an opportunistic human fungal pathogen that causes superficial mucosal and life-threatening bloodstream infections in individuals with a compromised immune system. Evolutionarily, it is closer to the non-pathogenic yeast Saccharomyces cerevisiae than to the most prevalent Candida bloodstream pathogen, C. albicans. C. glabrata is a haploid budding yeast that predominantly reproduces clonally. In this review, we summarize interactions of C. glabrata with the host immune, epithelial and endothelial cells, and the ingenious strategies it deploys to acquire iron and phosphate from the external environment. We outline various attributes including cell surface-associated adhesins and aspartyl proteases, biofilm formation and stress response mechanisms, that contribute to the virulence of C. glabrata. We further discuss how, C. glabrata, despite lacking morphological switching and secreted proteolytic activity, is able to disarm macrophage, dampen the host inflammatory immune response and replicate intracellularly.

Item Type:Article
Source:Copyright of this article belongs to Multidisciplinary Digital Publishing Institute.
Keywords:Candida Glabrata; Yeast Pathogens; Adherence; Biofilm Formation; Aspartyl Proteases; Stress Response Mechanisms; Host Immune Cells.
ID Code:118158
Deposited On:18 May 2021 07:07
Last Modified:18 May 2021 07:07

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