Singh, Bhagat ; Ahmed, Jasimuddin ; Biswas, Amit ; Paira, Rupankar ; Mandal, Swadhin K. (2021) Reduced Phenalenyl in Catalytic Dehalogenative Deuteration and Hydrodehalogenation of Aryl Halides Journal of Organic Chemistry . ISSN 0022-3263
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Official URL: http://doi.org/10.1021/acs.joc.1c00573
Related URL: http://dx.doi.org/10.1021/acs.joc.1c00573
Abstract
Dehalogenative deuteration reactions are generally performed through metal-mediated processes. This report demonstrates a mild protocol for hydrodehalogenation and dehalogenative deuteration of aryl/heteroaryl halides (39 examples) using a reduced odd alternant hydrocarbon phenalenyl under transition metal-free conditions and has been employed successfully for the incorporation of deuterium in various biologically active compounds. The combined approach of experimental and theoretical studies revealed a single electron transfer-based mechanism.
Item Type: | Article |
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Source: | Copyright of this article belongs to American Chemical Society. |
ID Code: | 118148 |
Deposited On: | 18 May 2021 06:05 |
Last Modified: | 18 May 2021 06:05 |
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