Tyagi, A. M. ; Srivastava, K. ; Kureel, J. ; Kumar, A. ; Raghuvanshi, A. ; Yadav, D. ; Maurya, R. ; Goel, A. ; Singh, D. (2012) Premature T cell senescence in Ovx mice is inhibited by repletion of estrogen and medicarpin: a possible mechanism for alleviating bone loss Osteoporosis International, 23 (3). pp. 1151-1161. ISSN 0937-941X
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Official URL: http://doi.org/10.1007/s00198-011-1650-x
Related URL: http://dx.doi.org/10.1007/s00198-011-1650-x
Abstract
Presently the relationship between CD28, biological marker of senescence, and ovariectomy is not well understood. We show that ovariectomy leads to CD28 loss on T cells and estrogen (E2) repletion and medicarpin (Med) inhibits this effect. We thus propose that Med/E2 prevents bone loss by delaying premature T cell senescence.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Springer Nature. |
| Keywords: | Immunological Senescence; Menopause; Osteoporosis; TNF-α |
| ID Code: | 117949 |
| Deposited On: | 07 May 2021 05:49 |
| Last Modified: | 07 May 2021 11:03 |
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