Goel, Atul ; Dixit, Manish ; Saeed, Uzma ; Kumar, Amit ; Siddiqi, Mohammad ; Tamrakar, Akhilesh ; Srivastava, Arvind (2008) Synthesis, Molecular Docking and PTP1B Inhibitory Activity of Functionalized 4,5-Dihydronaphthofurans and Dibenzofurans Medicinal Chemistry, 4 (1). pp. 18-24. ISSN 1573-4064
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Official URL: http://doi.org/10.2174/157340608783331515
Related URL: http://dx.doi.org/10.2174/157340608783331515
Abstract
Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Inhibitors of PTP1B showed increased insulin sensitivity and normalize plasma glucose level and thus are useful therapeutic agents for the treatment of diabetes. A series of functionalized 4,5-dihydronaphthofurans and dibenzofurans were synthesized, studied through molecular docking and evaluated for their PTP1B inhibitory activity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Bentham Science. |
| Keywords: | Diabetes, PTP1B Inhibitor, 4,5-dihydronaphthofuran, Dibenzofuran, Molecular Docking. |
| ID Code: | 117933 |
| Deposited On: | 06 May 2021 09:33 |
| Last Modified: | 06 May 2021 09:33 |
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