Dixit, Manish ; Tripathi, Brajendra K. ; Tamrakar, Akhilesh K. ; Srivastava, Arvind K. ; Kumar, Brijesh ; Goel, Atul (2007) Synthesis of benzofuran scaffold-based potential PTP-1B inhibitors Bioorganic & Medicinal Chemistry, 15 (2). pp. 727-734. ISSN 0968-0896
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Official URL: http://doi.org/10.1016/j.bmc.2006.10.053
Related URL: http://dx.doi.org/10.1016/j.bmc.2006.10.053
Abstract
Protein tyrosine phosphatase 1B (PTP-1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Studies have shown that PTP-1B knockout mice showed increased insulin sensitivity in muscle and liver as well as resistance to obesity. A series of hydroxy benzofuran methyl ketones and their naturally mimicking dimers and linear and angular furanochalcones and flavones have been evaluated as PTP-1B inhibitors. Screened compounds displayed good inhibitory activity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Diabetes; Protein Tyrosine Phosphatase 1B; Insulin Resistance; Benzofuran And Furanoflavonoid. |
| ID Code: | 117921 |
| Deposited On: | 06 May 2021 08:46 |
| Last Modified: | 06 May 2021 08:46 |
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