Synthesis of o,m-cymene-cored biaryls through a carbanion-induced ring transformation strategy

Singh, Fateh Veer ; Kumar, Amit ; Goel, Atul (2006) Synthesis of o,m-cymene-cored biaryls through a carbanion-induced ring transformation strategy Tetrahedron Letters, 47 (44). pp. 7767-7770. ISSN 0040-4039

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Official URL: http://doi.org/10.1016/j.tetlet.2006.08.105

Related URL: http://dx.doi.org/10.1016/j.tetlet.2006.08.105

Abstract

Aromatic compounds derived from two or more ‘isoprene units’ are the core structures found in several natural products of biological importance. Among them, cymene derivatives are of particular interest due to the unique structural and biological properties associated with them. In this letter, we describe an expeditious synthesis of cymene-cored unsymmetrical biaryls functionalized with donor and acceptor substituents prepared in excellent yields by the carbanion-induced ring transformation of 2H-pyran-2-ones with ketones.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Biaryl; Cymene; Isopropyl ketone; Lactone; Pyran-2-one.
ID Code:117918
Deposited On:06 May 2021 08:37
Last Modified:06 May 2021 08:37

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