Singh, Fateh V. ; Vatsyayan, Rit ; Roy, Uma ; Goel, Atul (2006) Arylanthranilodinitriles: A new biaryl class of antileishmanial agents Bioorganic & Medicinal Chemistry Letters, 16 (10). pp. 2734-2737. ISSN 0960-894X
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Official URL: http://doi.org/10.1016/j.bmcl.2006.02.012
Related URL: http://dx.doi.org/10.1016/j.bmcl.2006.02.012
Abstract
A series of anthranilodinitrile-based biaryls were synthesized and evaluated in vitro against extracellular promastigotes and intracellular amastigotes of Leishmania donovani. Among various screened compounds, a biaryl with trifluoromethyl group 5f showed 83% inhibition against promastigotes and 70% inhibition against amastigotes of L. donovani at 8 and 20 μg/mL concentrations, respectively.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Leishmaniasis; Anthranilodinitrile; Biaryls; Amastigotes; Promastigotes. |
| ID Code: | 117915 |
| Deposited On: | 06 May 2021 08:30 |
| Last Modified: | 06 May 2021 08:30 |
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