Sharon, Ashoke ; Pratap, Ramendra ; Vatsyayan, Rit ; Maulik, Prakas R. ; Roy, Uma ; Goel, Atul ; Ram, Vishnu Ji (2005) 6-Aryl-4-methylsulfanyl-2H-pyran-2-one-3-carbonitriles as PPAR-γ activators Bioorganic & Medicinal Chemistry Letters, 15 (14). pp. 3356-3360. ISSN 0960-894X
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Official URL: http://doi.org/10.1016/j.bmcl.2005.05.031
Related URL: http://dx.doi.org/10.1016/j.bmcl.2005.05.031
Abstract
Various 6-aryl-3-cyano/methoxycarbonyl-4-methylsulfanyl-2H-pyran-2-ones have been synthesized as a potential substitute of 2,4-thiazolidinedione head group to express potent PPAR-γ transactivation response. Some of the screened compounds have shown promising PPAR-γ agonistic activity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Diabetes; PPAR; Pyran-2-one; Transactivation. |
| ID Code: | 117910 |
| Deposited On: | 06 May 2021 07:36 |
| Last Modified: | 06 May 2021 07:36 |
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