Dixit, Manish ; Tripathi, Brajendra K. ; Srivastava, Arvind K. ; Goel, Atul (2005) Synthesis of functionalized acetophenones as protein tyrosine phosphatase 1B inhibitors Bioorganic & Medicinal Chemistry Letters, 15 (14). pp. 3394-3397. ISSN 0960-894X
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Official URL: http://doi.org/10.1016/j.bmcl.2005.05.024
Related URL: http://dx.doi.org/10.1016/j.bmcl.2005.05.024
Abstract
Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Studies have shown that PTP1B knock-out mice showed increased insulin sensitivity in muscle and liver as well as resistance to obesity. A series of functionalized acetophenones were synthesized and evaluated for their PTP1B inhibitory activity. Some of the screened compounds displayed good inhibitory activity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Diabetes; Protein; Tyrosine Phosphatase 1B; Acetophenone; Insulin Signaling. |
| ID Code: | 117909 |
| Deposited On: | 06 May 2021 07:34 |
| Last Modified: | 06 May 2021 07:34 |
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