Goel, Atul ; Agarwal, Nidhi ; Singh, Fateh V. ; Sharon, Ashoke ; Tiwari, Priti ; Dixit, Manish ; Pratap, Ramendra ; Srivastava, Arvind K. ; Maulik, Prakas R. ; Ram, Vishnu J. (2004) Antihyperglycemic activity of 2-methyl-3,4,5-triaryl-1 H -pyrroles in SLM and STZ models Bioorganic & Medicinal Chemistry Letters, 14 (5). pp. 1089-1092. ISSN 0960-894X
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Official URL: http://doi.org/10.1016/j.bmcl.2004.01.009
Related URL: http://dx.doi.org/10.1016/j.bmcl.2004.01.009
Abstract
Various 3,4,5-triarylpyrroles were synthesized and evaluated for their in vivo antihyperglycemic activity in sucrose-loaded (SLM) and/or streptozotocin-induced (STZ) diabetic rat models. Three of the test compounds, 2-methyl-4,5-diphenyl-3-substituted-phenyl-1H-pyrroles (3c, d and h) showed significant inhibition on postprandial hyperglycemia in normal rats post sucrose loaded. These compounds also showed lowering of plasma glucose level in STZ-induced diabetic rat model. Synthesis and antihyperglycemic activity of various 2-methyl-3,4,5-triaryl-1H-pyrroles is described.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 117904 |
| Deposited On: | 06 May 2021 07:16 |
| Last Modified: | 06 May 2021 07:16 |
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