Goel, Atul ; Mazur, Sharlyn J. ; Fattah, Rasem J. ; Hartman, Tracy L. ; Turpin, Jim A. ; Huang, Mingjun ; Rice, William G. ; Appella, Ettore ; Inman, John K. (2002) Benzamide-Based Thiolcarbamates: A New Class of HIV-1 NCp7 Inhibitors Bioorganic & Medicinal Chemistry Letters, 12 (5). pp. 767-770. ISSN 0960-894X
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Official URL: http://doi.org/10.1016/S0960-894X(02)00007-0
Related URL: http://dx.doi.org/10.1016/S0960-894X(02)00007-0
Abstract
The HIV-1 nucleocapsid protein NCp7, which contains two highly conserved zinc fingers, is being used as a novel target for AIDS therapy due to its pivotal role in viral replication and its mutationally intolerant nature. Herein we report a new class of NCp7 inhibitors that possess good antiviral activity with low cellular toxicity. Synthesis and antiviral activity of benzamide-based thiolcarbamates (5 and 6) are described.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 117893 |
| Deposited On: | 06 May 2021 05:38 |
| Last Modified: | 06 May 2021 05:38 |
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