Ram, V.J. ; Goel, A. ; Kandpal, M. ; Mittal, N. ; Goyal, N. ; Tekwani, B.L. ; Guru, P.Y. ; Rastogi, A.K. (1997) Tetraazaacenaphthene, tetraazaphenalene and 1,3,4-thiadiazole derivatives as potential leishmanicides Bioorganic & Medicinal Chemistry Letters, 7 (6). pp. 651-656. ISSN 0960-894X
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Official URL: http://doi.org/10.1016/S0960-894X(97)00086-3
Related URL: http://dx.doi.org/10.1016/S0960-894X(97)00086-3
Abstract
Synthesis and leishmanicidal activity of 1,3-dithiolanes (2a,b), 1,3-dithiane (2c), tetraazaacenaphthene (4a-h) and tetraazaphenalene (4i,j), imidazolidin-2-ylidene (5a,6a,b) and hexahydropyrimidin-2-ylidene (5b) derivatives are described. Some of the screened compounds have demonstrated significant leishmanicidal activity in in vitro and in vivo evaluations. Synthesis and leishmanicldal activity of the compounds 2a-c, 4a-j, 5a,b and 6a,b are described.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 117880 |
| Deposited On: | 06 May 2021 04:42 |
| Last Modified: | 06 May 2021 04:42 |
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