In Vitro Antifungal Susceptibility Profile and Correlation of Mycelial and Yeast Forms of Molecularly Characterized Histoplasma capsulatum Strains from India

Kathuria, Shallu ; Singh, Pradeep K. ; Meis, Jacques F. ; Chowdhary, Anuradha (2014) In Vitro Antifungal Susceptibility Profile and Correlation of Mycelial and Yeast Forms of Molecularly Characterized Histoplasma capsulatum Strains from India Antimicrobial Agents and Chemotherapy, 58 (9). pp. 5613-5616. ISSN 0066-4804

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Official URL: http://doi.org/10.1128/AAC.02973-14

Related URL: http://dx.doi.org/10.1128/AAC.02973-14

Abstract

The antifungal susceptibility profiles of the mycelial and yeast forms of 23 Histoplasma capsulatum strains from pulmonary and disseminated histoplasmosis patients in India are reported here. The MIC data of this dimorphic fungus had good agreement between both forms for azoles, amphotericin B, and caspofungin. Therefore, the use of mycelial inocula for H. capsulatum antifungal susceptibility testing is suggested, which is less time-consuming vis-à-vis the yeast form, which requires 6 to 8 weeks for conversion.

Item Type:Article
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ID Code:117546
Deposited On:26 Apr 2021 11:58
Last Modified:26 Apr 2021 12:02

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