In vitro combination of voriconazole with micafungin against azole-resistant clinical isolates of Aspergillus fumigatus from different geographical regions

Fakhim, Hamed ; Vaezi, Afsane ; Dannaoui, Eric ; Sharma, Cheshta ; Mousavi, Bita ; Chowdhary, Anuradha ; Meis, Jacques F. ; Badali, Hamid (2018) In vitro combination of voriconazole with micafungin against azole-resistant clinical isolates of Aspergillus fumigatus from different geographical regions Diagnostic Microbiology and Infectious Disease, 91 (3). pp. 266-268. ISSN 0732-8893

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Official URL: http://doi.org/10.1016/j.diagmicrobio.2018.03.003

Related URL: http://dx.doi.org/10.1016/j.diagmicrobio.2018.03.003

Abstract

In vitro interaction of voriconazole with micafungin was evaluated against 33 clinical Aspergillus fumigatus isolates, including azole-resistant (n = 31) and -susceptible (n = 2) isolates. Interaction was synergistic for only 1 resistant isolate carrying the TR34/L98H mutation. No antagonistic effects were observed for 96.8% of azole-resistant isolates.

Item Type:Article
Source:Copyright of this article belongs to Elsevier B.V.
Keywords:In vitro Interactions; Voriconazole; Micafungin; Aspergillus fumigatus.
ID Code:117377
Deposited On:19 Apr 2021 11:38
Last Modified:19 Apr 2021 11:38

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