Ghorai, Manas K. ; Shukla, Dipti ; Das, Kalpataru (2009) Enantioselective Syntheses of Morpholines and Their Homologues via SN2-Type Ring Opening of Aziridines and Azetidines with Haloalcohols The Journal of Organic Chemistry, 74 (18). pp. 7013-7022. ISSN 0022-3263
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Official URL: http://doi.org/10.1021/jo901297d
Related URL: http://dx.doi.org/10.1021/jo901297d
Abstract
A highly regio- and stereoselective strategy for the syntheses in high yield and enantioselectivity of a variety of substituted nonracemic morpholines and their homologues is described. The reaction proceeds via an S(N)2-type ring opening of activated aziridines and azetidines by suitable halogenated alcohols in the presence of Lewis acid followed by base-mediated intramolecular ring closure of the resulting haloalkoxy amine.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 117270 |
| Deposited On: | 15 Apr 2021 10:49 |
| Last Modified: | 15 Apr 2021 10:49 |
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