Ghorai, Manas K. ; Tiwari, Deo Prakash (2010) Lewis Acid Catalyzed Highly Stereoselective Domino-Ring-Opening Cyclization of Activated Aziridines with Enolates: Synthesis of Functionalized Chiral γ-Lactams The Journal of Organic Chemistry, 75 (18). pp. 6173-6181. ISSN 0022-3263
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Official URL: http://doi.org/10.1021/jo101004x
Related URL: http://dx.doi.org/10.1021/jo101004x
Abstract
A highly enantio- and diastereoselective Lewis acid catalyzed SN2-type ring opening followed by cyclization of aziridines with active methylene carbon nucleophiles to functionalized chiral γ-lactams in a domino fashion has been developed. γ-Lactams have been desulfonated and decarboxylated, providing pyrrolidone-3-carboxylate and N-tosylpyrrolidinone derivatives, respectively, in good yields.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 117121 |
| Deposited On: | 15 Apr 2021 08:01 |
| Last Modified: | 15 Apr 2021 08:01 |
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