Influence of surface chemistry of mesoporous alumina with wide pore distribution on controlled drug release

Kapoor, Shobhna ; Hegde, Rajesh ; Bhattacharyya, Aninda J. (2009) Influence of surface chemistry of mesoporous alumina with wide pore distribution on controlled drug release Journal of Controlled Release, 140 (1). pp. 34-39. ISSN 0168-3659

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Official URL: http://doi.org/10.1016/j.jconrel.2009.07.015

Related URL: http://dx.doi.org/10.1016/j.jconrel.2009.07.015

Abstract

The crucial role of the drug carrier surface chemical moeities on the uptake and in vitro release of drug is discussed here in a systematic manner. Mesoporous alumina with a wide pore size distribution (2–7 nm) functionalized with various hydrophilic and hydrophobic surface chemical groups was employed as the carrier for delivery of the model drug ibuprofen. Surface functionalization with hydrophobic groups resulted in low degree of drug loading (approximately 20%) and fast rate of release (85% over a period of 5 h) whereas hydrophilic groups resulted in a significantly higher drug payloads (21%–45%) and slower rate of release (12%–40% over a period of 5 h). Depending on the chemical moiety, the diffusion controlled (∝ time− 0.5) drug release was additionally observed to be dependent on the mode of arrangement of the functional groups on the alumina surface as well as on the pore characteristics of the matrix. For all mesoporous alumina systems the drug dosages were far lower than the maximum recommended therapeutic dosages (MRTD) for oral delivery. We envisage that the present study would aid in the design of delivery systems capable of sustained release of multiple drugs.

Item Type:Article
Source:Copyright of this article belongs to Elsevier B.V.
Keywords:Controlled Drug Delivery; Mesoporous Alumina; Surface Chemistry; Pore Morphology.
ID Code:116883
Deposited On:20 May 2021 05:16
Last Modified:20 May 2021 05:16

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