Ramachandran, U ; Mita, Alka ; Prasad V., Bharatam (2004) Studies on some glitazones having pyridine as the linker unit Bioorganic & Medicinal Chemistry, 12 (4). pp. 655-662. ISSN 0968-0896
Full text not available from this repository.
Official URL: http://doi.org/10.1016/j.bmc.2003.11.027
Related URL: http://dx.doi.org/10.1016/j.bmc.2003.11.027
Abstract
Molecular modeling on various well-known glitazones carrying a pyridine ring instead of benzene ring as the middle linker unit showed conformational rigidity as compared to their parent molecules. Blocking the lone pair of electrons on the pyridine N, made them flexible once again. A few representatives of these analogues were synthesized and their efficacy as PPARγ agonists evaluated. Semi-empirical AM1 studies and synthesis of pyridine derivatives of some glitazones were done. Their efficacy as PPARγ agonists was evaluated.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier B.V. |
| Keywords: | Type 2 Diabetes; Am1 Calculations; Pyridine Analogues of Tzds; Conformational Rigidity; Transactivitaion; Pparg Agonists. |
| ID Code: | 116670 |
| Deposited On: | 12 Apr 2021 11:42 |
| Last Modified: | 12 Apr 2021 11:42 |
Repository Staff Only: item control page
