Guanylthiourea derivatives as potential antimalarial agents: Synthesis, in vivo and molecular modelling studies

Bhagat, Shweta ; Arfeen, Minhajul ; Adane, Legesse ; Singh, Savita ; Singh, Prati Pal ; Chakraborti, Asit K. ; Bharatam, Prasad V. (2017) Guanylthiourea derivatives as potential antimalarial agents: Synthesis, in vivo and molecular modelling studies European Journal of Medicinal Chemistry, 135 . pp. 339-348. ISSN 0223-5234

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Official URL: http://doi.org/10.1016/j.ejmech.2017.04.022

Related URL: http://dx.doi.org/10.1016/j.ejmech.2017.04.022

Abstract

Guanylthiourea (GTU) derivatives were identified as possible anti-malarial agents, recently, using in vitro studies on Plasmodium falciparum. This article gives an account of the in vivo anti-malarial activity of GTU derivatives against experimental rodent malaria. A total of 20 synthesized GTU derivatives were evaluated for in vivo antimalarial activity, out of which six showed encouraging results; one compound appeared to have curative potential. Molecular docking and molecular dynamics analysis were carried out to understand the molecular level interactions.

Item Type:Article
Source:Copyright of this article belongs to FOIA Privacy.
Keywords:Anti-malarials; Curative Agent; Guanylthiourea; In Vivo Testing; Molecular Docking; Pfdhfr.
ID Code:116334
Deposited On:12 Apr 2021 09:24
Last Modified:12 Apr 2021 09:24

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