Yin, D. ; Lunt, E. J. ; Barman, A. ; Hawkins, A. R. ; Schmidt, H. (2007) Microphotonic control of single molecule fluorescence correlation spectroscopy using planar optofluidics Optics Express, 15 (12). p. 7290. ISSN 1094-4087
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Official URL: http://doi.org/10.1364/OE.15.007290
Related URL: http://dx.doi.org/10.1364/OE.15.007290
Abstract
We demonstrate the implementation of fluorescence correlation spectroscopy (FCS) on a chip. Full planar integration is achieved by lithographic definition of sub-picoliter excitation volumes using intersecting solid and liquid-core optical waveguides. Concentration dependent measurements on dye molecules with single molecule resolution are demonstrated. Theoretical modeling of the FCS autocorrelation function in microstructured geometries shows that the FCS behavior can be controlled over a wide range by tailoring the micro-photonic environment. The ability to perform correlation spectroscopy using silicon photonics without the need for free-space microscopy permits implementation of numerous diagnostic applications on compact planar optofluidic devices.
Item Type: | Article |
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Source: | Copyright of this article belongs to Optical Society of America. |
ID Code: | 116242 |
Deposited On: | 08 Apr 2021 04:50 |
Last Modified: | 08 Apr 2021 04:50 |
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