Sahu, N ; Pal, Chiranjib ; Mandal, Nirup B. ; Banerjee, Sukdeb ; Raha, Mausumi ; Kundu, Ashis P. ; Basu, Anirban ; Ghosh, Monidipa ; Roy, Keshab ; Bandyopadhyay, Santu (2002) Synthesis of a novel quinoline derivative, 2-(2-methylquinolin-4-ylamino)-N-phenylacetamide—a potential antileishmanial agent Bioorganic & Medicinal Chemistry, 10 (6). pp. 1687-1693. ISSN 0968-0896
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Official URL: http://doi.org/10.1016/S0968-0896(02)00046-9
Related URL: http://dx.doi.org/10.1016/S0968-0896(02)00046-9
Abstract
Some novel quinoline derivatives were prepared and tested for antileishmanial activity. 2-(2-Methylquinolin-4-ylamino)-N-phenylacetamide (2) was found to be significantly more active than the standard antileishmanial drug sodium antimony gluconate (SAG) in reducing the parasite load both in the spleen and liver at a much lower concentration in hamster models. The results suggest that the compound could be exploited as an antileishmanial drug. Some novel quinoline derivatives were prepared and tested for antileishmanial activity in hamster models. 2-(2-Methylquinolin-4-ylamino)-N-phenylacetamide (2) was found to be significantly more active than the standard antileishmanial drug sodium antimony gluconate (SAG) in reducing the parasite load, both in the spleen and liver, at a much lower concentration in hamster models. The results suggest that the compound could be exploited as an antileishmanial drug.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier B.V. |
| ID Code: | 115690 |
| Deposited On: | 18 Mar 2021 04:52 |
| Last Modified: | 19 Mar 2021 12:06 |
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