Mukhopadhyay, Rupanjan ; Mishra, Manoj K. ; Basu, Anirban ; Bishayi, Biswadev (2009) Modulation of Steroidogenic Enzymes in Murine Lymphoid Organs After Immune Activation Immunological Investigations, 38 (1). pp. 14-30. ISSN 0882-0139
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Official URL: http://doi.org/10.1080/08820130802480570
Related URL: http://dx.doi.org/10.1080/08820130802480570
Abstract
To study the effects of immune cell activation by a protein antigen or lymphoid tissue derived cytokines on peripheral steroidogenesis activities of 3β HSD and 17β HSD was measured in lymphoid organs of control and BSA immunized mice after 3 weeks treatment. We demonstrated the presence of 3βHSD and 17βHSD in the lymphoid organs after active immunization. We found elevated serum corticosterone after 3 weeks of antigen administration in presence of CFA and a higher serum IL-6 level that also alter lymphoid tissue cytokine responses like TNF-α, IL-12p70, and IL-6, among which IL-12p70 and TNF-α down-regulate the activity of steroidogenic enzymes in the thymus during an immune response.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Informa UK Limited. |
| Keywords: | Cytokines; Glucocorticoid; Hpa Axis; Immunization; Lymphoid Organs; Steroidogenic Enzymes. |
| ID Code: | 115661 |
| Deposited On: | 18 Mar 2021 04:34 |
| Last Modified: | 18 Mar 2021 04:34 |
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