Mukhopadhyay, Rupanjan ; Mishra, Manoj K. ; Basu, Anirban ; Bishayi, Biswadev (2010) Effect of particulate antigenic stimulation or in vivo administration of interleukin-6 on the level of steroidogenic enzymes in adrenal glands and lymphoid tissues of mice with parallel alteration in endogenous inflammatory cytokine level Cellular Immunology, 261 (1). pp. 23-28. ISSN 0008-8749
Full text not available from this repository.
Official URL: http://doi.org/10.1016/j.cellimm.2009.10.005
Related URL: http://dx.doi.org/10.1016/j.cellimm.2009.10.005
Abstract
To study the effects of sheep red blood cells (SRBC), viable Escherichia coli inoculation and IL-6 administration on steroidogenesis, activities and expression of hydroxy steroid dehydrogenase enzymes (3βHSD and 17βHSD) were measured in lymphoid organs of control and infected mice after 3 weeks treatment. Serum testosterone and cytokine levels were also estimated. Reduced expression of 3βHSD4 was found in the spleen of treated groups as compared to control, whereas the 3βHSD4 expression was increased in the thymus and lymph gland after stimulation. Reduced serum testosterone level was observed after antigenic stimulation and also altered serum IL-12p70, TNF-α, IFN-γ, MCP-1 or IL-10 level. These studies provide the evidence of expression of 3βHSD4 enzyme in the murine lymphoid organs after particulate antigen stimulation along with a parallel alteration in endogenous cytokine level.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier B.V. |
| Keywords: | Cytokine; Lymphoid Organ; Particulate Antigen; Steroidogenic Enzyme; Testosterone. |
| ID Code: | 115654 |
| Deposited On: | 18 Mar 2021 04:32 |
| Last Modified: | 18 Mar 2021 04:32 |
Repository Staff Only: item control page
