Singh, Sunit Kumar ; Nazmi, Arshed ; Dutta, Kallol ; Basu, Anirban (2010) Antiviral and Neuroprotective Role of Octaguanidinium Dendrimer-Conjugated Morpholino Oligomers in Japanese Encephalitis PLoS Neglected Tropical Diseases, 4 (11). e892. ISSN 1935-2735
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Official URL: http://doi.org/10.1371/journal.pntd.0000892
Related URL: http://dx.doi.org/10.1371/journal.pntd.0000892
Abstract
Japanese encephalitis (JE), caused by a mosquito-borne flavivirus, is endemic to the entire south-east Asian and adjoining regions. Currently no therapeutic interventions are available for JE, thereby making it one of the most dreaded encephalitides in the world. An effective way to counter the virus would be to inhibit viral replication by using anti-sense molecules directed against the viral genome. Octaguanidinium dendrimer-conjugated Morpholino (or Vivo-Morpholino) are uncharged anti-sense oligomers that can enter cells of living organisms by endocytosis and subsequently escape from endosomes into the cytosol/nuclear compartment of cells. We hypothesize that Vivo-Morpholinos generated against specific regions of 3′ or 5′ untranslated regions of JEV genome, when administered in an experimental model of JE, will have significant antiviral and neuroprotective effect.
Item Type: | Article |
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Source: | Copyright of this article belongs to Public Library of Science. |
ID Code: | 115645 |
Deposited On: | 18 Mar 2021 04:25 |
Last Modified: | 18 Mar 2021 04:25 |
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