Handore, Kishor L. ; Jadhav, Prakash D. ; Hazra, Bibhabasu ; Basu, Anirban ; Reddy, D. Srinivasa (2015) Total Syntheses and Biological Evaluation of (±)-Botryosphaeridione, (±)-Pleodendione, 4-epi-Periconianone B, and Analogues ACS Medicinal Chemistry Letters, 6 (11). pp. 1117-1121. ISSN 1948-5875
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Official URL: http://doi.org/10.1021/acsmedchemlett.5b00241
Related URL: http://dx.doi.org/10.1021/acsmedchemlett.5b00241
Abstract
The total syntheses of (±)-botryosphaeridione, (±)-pleodendione, (±)-hoaensieremodione, 4-epi-periconianone B, and their analogues have been accomplished for the first time. All the synthesized target compounds were screened in neural anti-inflammatory assays using LPS induced microglia cells (N9). Among them, compounds 1 and 21 were identified as potential lead compounds for further profiling.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| Keywords: | Natural Product; Total Synthesis; Antineuroinflammatory Agents; Botryosphaeridione; Pleodendione. |
| ID Code: | 115541 |
| Deposited On: | 17 Mar 2021 10:36 |
| Last Modified: | 17 Mar 2021 10:36 |
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