Shanmugam, Thanigaivel ; Joshi, Nitin ; Ahamad, Nadim ; Deshmukh, Atul ; Banerjee, Rinti (2020) Enhanced absorption, and efficacy of oral self-assembled paclitaxel nanocochleates in multi-drug resistant colon cancer International Journal of Pharmaceutics, 586 . p. 119482. ISSN 0378-5173
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Official URL: http://doi.org/10.1016/j.ijpharm.2020.119482
Related URL: http://dx.doi.org/10.1016/j.ijpharm.2020.119482
Abstract
Chemotherapy in drug-resistant cancers remains a challenge. Owing to associated poor bioavailability, oral administration of hydrophobic anticancer drugs like paclitaxel has been quite challenging, with the scenario being further complicated by Pgp efflux in drug-resistant tumours. We developed a novel nanocochleates (CPT) system encapsulating paclitaxel (PTX) to treat resistant colon cancer by oral administration.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier B.V. |
| Keywords: | Colon Cancer; Nanocochleates; Phosphatidylserine; Paclitaxel;Drug Resistance; Pgp; Oral Delivery. |
| ID Code: | 115192 |
| Deposited On: | 16 Mar 2021 11:49 |
| Last Modified: | 16 Mar 2021 11:49 |
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