Ashraf, M.Zahid ; Khan, M.S.Y. ; Hameed, Hakeem Abdul ; Hussain, M.Ejaz ; Fahim, M. (1999) Endothelium modulated vasorelaxant response of a polypharmaceutical herbal drug (lipotab) and its individual constituents Journal of Ethnopharmacology, 66 (1). pp. 97-102. ISSN 03788741
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Official URL: http://doi.org/10.1016/S0378-8741(98)00226-8
Related URL: http://dx.doi.org/10.1016/S0378-8741(98)00226-8
Abstract
The present study was undertaken to examine the endothelium modulated effects of polypharmaceutical drug lipotab and its individual ingredients in isolated aortic rings of rat. Endothelium intact and denuded aortic rings were precontracted with phenylephrine 10−6 M and drugs were added in cumulative manner in concentration ranging from 1 to 50 μg/ml. The results demonstrated an endothelium-dependent vasorelaxant effect of lipotab and its individual ingredients, with the exception of nicotinic acid. The dose dependent relaxant response of nicotinic acid was not altered significantly in the endothelium-denuded rings, suggesting a direct effect of the drug on the vascular smooth muscle. Vasorelaxant effect of lipotab and its individual constituents suggests the therapeutic potential of these compounds in certain cardiovascular diseases.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier B.V. |
| Keywords: | Endothelium; Vascular Smooth Muscle; Alium Sativum; Lipotab; Curcuma longa; Nepeta hindoostana. |
| ID Code: | 115130 |
| Deposited On: | 16 Mar 2021 10:48 |
| Last Modified: | 16 Mar 2021 10:48 |
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