Chorghade, Mukund S. ; Mohapatra, Debendra K. ; Sahoo, Gokarneswar ; Gurjar, Mukund K. ; Mandlecha, Manish V. ; Bhoite, Nitin ; Moghec, Santosh ; Raines, Ronald T. (2008) Practical syntheses of 4-fluoroprolines Journal of Fluorine Chemistry, 129 (9). pp. 781-784. ISSN 0022-1139
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00221...
Related URL: http://dx.doi.org/10.1016/j.jfluchem.2008.06.024
Abstract
4-Fluoroprolines are among the most useful nonnatural amino acids in chemical biology. Here, practical routes are reported for the synthesis of the 2S,4R, 2S,4S, and 2R,4S diastereomers of 4-fluoroproline. Each route starts with (2S,4R)-4-hydroxyproline, which is a prevalent component of collagen and hence readily available, and uses a fluoride salt to install the fluoro group. Hence, the routes provide process-scale access to these useful nonnatural amino acids.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Collagen; 4-Fluoroproline; 4-Hydroxyproline; Nonnatural Amino Acid; Process-scale Synthesis |
| ID Code: | 11452 |
| Deposited On: | 09 Nov 2010 06:18 |
| Last Modified: | 02 Jun 2011 09:38 |
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