Gurjar, Mukund K. ; Ravindranadh, Somu V. ; Sankar, Kuppusamy ; Karmakar, Sukhen ; Cherian, Joseph ; Chorghade, Mukund S. (2003) Synthesis of spirocycles via ring closing metathesis of heterocycles carrying gem-diallyl substituents obtained via ring opening of (halomethyl) cyclopropanes with allyltributyltin Organic & Biomolecular Chemistry, 1 . pp. 1366-1373. ISSN 1477-0520
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Abstract
In the presence of allyl tri-n-butyltin-AIBN, cyclopropylmethyl bromides/xanthates undergo ring-opening reaction with concomitant formation of geminal diallyl derivatives in good yields. The ring closing metathesis reactions on geminal diallyl derivatives with Grubbs' catalyst provided spirocyclopentenyl products. Combination of these two methodologies has been applied to the synthesis of mono-, bis-cyclopentyl-carbohydrates as well as spirocyclopentylproline derivatives.
Item Type: | Article |
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Source: | Copyright of this article belongs to Royal Society of Chemistry. |
ID Code: | 11431 |
Deposited On: | 09 Nov 2010 06:08 |
Last Modified: | 16 May 2016 20:53 |
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