Effects of pretransplantation treatment with rituximab on outcomes of autologous stem-cell transplantation for non-hodgkin's lymphoma

Hoerr, Amy L. ; Gao, Feng ; Hidalgo, Josephine ; Tiwari, Divya ; Blum, Kristie A. ; Mathews, Vikram ; Adkins, Douglas R. ; Blum, William ; Devine, Steven ; Vij, Ravi ; Goodnough, Lawrence T. ; Dipersio, John F. ; Khoury, Hanna J. (2004) Effects of pretransplantation treatment with rituximab on outcomes of autologous stem-cell transplantation for non-hodgkin's lymphoma Journal of Clinical Oncology, 22 (22). pp. 4561-4566. ISSN 0732-183X

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Official URL: http://ascopubs.org/doi/full/10.1200/JCO.2004.05.0...

Related URL: http://dx.doi.org/10.1200/JCO.2004.05.035

Abstract

Purpose: To analyze the effects of preautografting treatment with rituximab (R) on stem-cell mobilization, post-transplantation complications, engraftment, disease-free survival, and overall survival in patients with non-Hodgkin's lymphoma (NHL). Patients and Methods: Single-institution retrospective comparative outcome analysis in a cohort of 273 relapsed chemosensitive NHL patients of whom 127 (47%) received R pretransplantation. Results: R was administered a median of 3 months before autologous transplantation. When compared to the nonrituximab group, R patients were older (56 v 50 years; P < .001), and had delays in post-transplantation platelets recovery (39 v 27 days; P = .001). Pretransplantation R did not affect stem-cell mobilization, post-transplantation early complications, duration of hospitalization, or mortality rates at days 30 and 100. In contrast to patients with low-grade NHL, both disease-free and overall survival rates were significantly better when R was included in the pretransplantation salvage therapy for patients with intermediate-grade NHL. Conclusion: In this large, single-center retrospective analysis, pretransplantation treatment with R was associated with improved survival in patients with intermediate-grade NHL, at the price, however, of a delay in platelet engraftment.

Item Type:Article
Source:Copyright of this article belongs to American Society of Clinical Oncology.
ID Code:114144
Deposited On:07 Jun 2018 10:37
Last Modified:08 Jun 2018 07:57

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